Barcelona have confirmed Ousmane Dembele, Samuel Umtiti and Gavi have tested positive for Covid-19.
The Blaugrana were previously hit with positives for Clement Lenglet, Dani Alves, Jordi Alba and Alejandro Balde in the past week.
A statement on the club's website on Wednesday read: "The footballers Dembele, Umtiti and Gavi are positive for COVID-19 after PCR tests on the squad.
"The players are in good health and self-isolating at home. The club has reported the cases to the relevant authorities."
Umtiti has largely been out of favour at Camp Nou this season, playing just once across all competitions, while Dembele has only managed eight appearances (four starts) having spent a significant period out through injury.
Seventh place in La Liga
Gavi is the club's third-highest appearance maker in this campaign, though, with the 17-year-old midfielder playing 22 times, 17 of which have been starts. Only Sergio Busquets has featured more often.
The Blaugrana sit in seventh place in LaLiga, two points off fourth and 18 behind leaders Real Madrid, and travel to face Real Mallorca next on January 2.
